HUBUNGAN KREATININ SERUM DENGAN pH URINE PADA PENDERITA GAGAL GINJAL KRONIS DI R.S. BHAYANGKARA H.S. SAMSOERI MERTOJOSO SURABAYA

Abstract

Chronic renal failure is a disease with progressive decline in kidney function over months or years.
Chronic renal failure is defined as kidney damage and / or decreased Glomerular Filtration Rate (GFR) <60
mL / min / 1.73m2 for at least 3 months. Renal function examination with a marker of good renal filtration is
serum creatinine level because serum creatinine is in a relatively constant state and is not influenced by protein
from the diet. If renal dysfunction occurs, the creatinine filtration ability will decrease and the serum creatinine
will increase. When kidney function is severely decreased, there is a buildup of anions from weak acids in body
fluids that are not excreted by the kidneys. In addition, a decrease in the glomerular filtration rate reduces the
excretion of phosphate and NH
4

+
, thereby reducing the amount of HCO
3
-
that is re-added to body fluids. Thus,
chronic renal failure can lead to severe metabolic acidosis. Metabolic acidosis makes the pH of the blood acidic
and affects the pH level of urine. A decrease in urine pH indicates that the body is experiencing a metabolic
acidosis state. The purpose of this study was to determine the relationship between serum creatinine levels and
urine pH in patients with chronic kidney failure. This type of research is a descriptive study on 30 patients with
chronic renal failure who undergo hemodialysis. The serum creatinine level and urine pH were examined. The
Kolmogorov-Smirnov test was used to test the data normality and the Spearman rank test was used to test the
relationship between two variables. From the statistic result, it could be concluded that there wa a relationship
between serum creatinine levels and urine pH in patients with chronic kidney failure.

Keywords : Chronic renal failure;  Serum creatinine; Urine pH