HUBUNGAN NILAI SEL POLIMORFONUKLEAR (NEUTROFIL, EOSINOFIL, DAN BASOFIL) DENGAN KADAR PROCALCITONIN PADA PASIEN SEPSIS BAKTERI

Abstract

epsis occurs because of SIRS (Sistemic Inflammatory Respon Syndrome)
accompanied by infection. The infections cause by bacteria is called bacterial sepsis. Serious infection correlates with increased systemic immune activation, unbalanced, destructive, and can lead to organ failure until death. Procalcitonin as a biomarker is used to distinguish both bacterial and non-bacterial sepsis. Polymorphonuclear counting cells
(Neutrophils, Eosinophils, and Basophils) can be used as a screening for infection. The goal of this research is to know the relationship between polymorphonuclear counting cell (Neutrophils, Eosinophils and Basophils) with procalcitonin levels in bacterial sepsis patients. This research was conducted in January-June 2018 at Dr. Soetomo Surabaya with cross sectional method to 68 samples of bacterial sepsis patients. Procalcitonin levels were calculated with vidas BRHMS PCT Analyzer, and the Polymorphonuclear cell values (Neutrophils, Eosinophils, and Basophils) were calculated with the Sysmex-Xn 1000 Hematoanalyzer tool. The results showed that the average value of Neutrophil cell was 81,766%, Eosinophil cell was 1,041%, Basophil cell was 0,282%, and the average value of procalcitonin level was 10,702%. Determination of the relationship between Polymorphonuclear counting cell value and procalcitonin level was tested using Spearman correlation. The end result showed a relation between Neutrophil cell value and procalcitonin level was positively associated with (r = 0.350, p = 0.003), Eosinophil with procalcitonin was negatively associated with (r = -0.275, p = 0.023) and basophils with procalcitonin were negatively associated with = -0.338, p = 0.005).

Keyword : Bacterial sepsis, procalcitonin, Polymorphonuclear cells